Exploring America’s highways is about more than just reaching your destination; it’s the incredible stops, unique attractions, and rich history you encounter along the way. From winding coastal routes to historic roads carved through the heart of the country, these famous highways set the scene for unforgettable adventures.

Here are some of the most iconic highways in the U.S. and the must-visit destinations you should add to your itinerary.

1. Route 66 - The Main Street of America

Stretching from Chicago to Santa Monica, Route 66 is a legendary road trip experience. This iconic highway, often called "The Mother Road," offers a nostalgic drive peppered with quirky landmarks and classic Americana.

Must-Visit Stops:

  • The Gateway Arch in St. Louis, Missouri: Start your trip with an iconic view from one of America’s most famous landmarks.
  • Cadillac Ranch in Amarillo, Texas: Spray-paint one of the brightly colored, half-buried Cadillacs for a truly unique memory.
  • Santa Monica Pier in California: End your Route 66 adventure at the pier, where you’ll find a Ferris wheel, ocean views, and the perfect sunset.

2. Pacific Coast Highway (Highway 1) - California Coastal Beauty

California’s Pacific Coast Highway is one of the most scenic drives in the world. Hugging the coastline from northern California to Southern California, this highway spans majestic clifftop views, idyllic beaches, and vibrant cities.

Must-Visit Stops:

  • Big Sur: Drive along dramatic cliffs where the sea meets rugged mountains, and stop at McWay Falls for breathtaking photo ops.
  • Bixby Creek Bridge: Snap a picture of this iconic bridge, a symbol of the PCH’s scenic beauty.
  • Santa Barbara: Stroll through historic downtown areas and relax on pristine beaches with a backdrop of the Santa Ynez Mountains.

3. Blue Ridge Parkway - A Drive Through the Appalachians

The Blue Ridge Parkway winds through the Appalachian Mountains, connecting Virginia’s Shenandoah National Park to North Carolina’s Great Smoky Mountains National Park. Known for its sweeping mountain views, this highway offers serenity and natural beauty.

Must-Visit Stops:

  • Humpback Rocks in Virginia: Hike this trail to enjoy panoramic views of the Blue Ridge Mountains.
  • Linville Falls in North Carolina: Take a short walk to witness this dramatic multi-tiered waterfall.
  • Great Smoky Mountains National Park: Complete the drive by exploring the park’s lush forests and iconic fog-covered peaks.

4. Overseas Highway - Island Hopping in Florida

The Overseas Highway connects mainland Florida to the islands of the Florida Keys with 113 miles of stunning ocean views. This engineering masterpiece offers numerous chances to stop and enjoy tropical bliss.

Must-Visit Stops:

  • John Pennekamp Coral Reef State Park: Snorkel or take a glass-bottom boat tour to explore the vibrant coral reefs.
  • Key Largo: Sample fresh seafood and enjoy laid-back vibes at waterfront bars.
  • Mallory Square in Key West: Watch street performers and catch a famous Keys sunset at this lively plaza.

5. Great River Road - Following the Mississippi River

The Great River Road traces the mighty Mississippi River from its source in Minnesota to its endpoint in Louisiana. This route takes you through charming riverside towns and offers a glimpse into America’s diverse history and culture.

Must-Visit Stops:

  • Minneapolis and Saint Paul, Minnesota: Begin the trip with urban culture near the Mississippi’s source.
  • Vicksburg National Military Park in Mississippi: Explore the rich Civil War history preserved along the road.
  • New Orleans, Louisiana: Conclude with the French Quarter’s vibrant nightlife and the unmistakable flavors of Cajun and Creole cuisine.

6. Going-to-the-Sun Road - Montana’s Glacier National Park

For breathtaking mountain landscapes, clear glacial lakes, and rugged roads, Going-to-the-Sun Road delivers an unparalleled driving experience. This 50-mile route crosses pristine terrain in Glacier National Park.

Must-Visit Stops:

  • Logan Pass: At the highest point of the road, enjoy incredible views and keep an eye out for mountain goats.
  • Hidden Lake Overlook: A short hike rewards travelers with stunning vistas and wildlife spotting opportunities.
  • Sun Point Nature Trail: Walk along the trail to admire waterfalls and meadow views before driving deeper into the park.

7. Highway 61 - The Blues Highway

Known as "The Blues Highway," Highway 61 stretches from New Orleans to Wyoming, Minnesota, but its most famous section is the stretch that runs through Mississippi. The road is deeply rooted in music history, offering an immersive cultural experience.

Must-Visit Stops:

  • Memphis, Tennessee: Visit Beale Street, Graceland, and the National Civil Rights Museum.
  • Clarksdale, Mississippi: Stop at the Delta Blues Museum and the famous crossroads where Robert Johnson is said to have made his legendary deal.
  • New Orleans, Louisiana: Experience the rhythm of the blues alongside vibrant food and culture.

8. Route 100 - Vermont’s Scenic Byway

If you’re looking for New England charm and postcard-worthy landscapes, Vermont’s Route 100 is a must-drive. It’s especially stunning in the fall, when the foliage transforms into fiery hues of orange and red.

Must-Visit Stops:

  • Stowe, Vermont: A classic ski town setting with beautiful nature trails and cozy eateries.
  • Warren Falls: Take a swim or enjoy the sight of these serene cascading waterfalls.
  • Ben & Jerry’s Factory in Waterbury: Indulge your sweet tooth and tour this iconic Vermont ice cream factory.

9. Alaska Highway - The Last Frontier

Built to connect the lower 48 states to Alaska, this highway offers an unparalleled wilderness experience. Spanning from British Columbia, Canada, to Delta Junction, Alaska, the route is perfect for adventurers craving rugged beauty.

Must-Visit Stops:

  • Liard River Hot Springs in British Columbia: Relax in one of Canada’s largest natural hot springs.
  • Kluane National Park in Yukon: Discover glaciers and rugged mountain landscapes.
  • Fairbanks, Alaska: Once you finish the route, enjoy the midnight sun or the magic of the Northern Lights.

10. Hana Highway - Maui’s Tropical Escape

Hawai’i’s Hana Highway combines adventure with paradise. This narrow, winding route along Maui’s coastline offers lush rainforests, cascading waterfalls, and dramatic ocean views.

Must-Visit Stops:

  • Twin Falls: Enjoy fresh coconut juice and tropical smoothies from the roadside stand before hiking to a waterfall.
  • Waianapanapa State Park: Find the famous black sand beaches that are both unique and breathtaking to photograph.
  • Hana Town: End your trip here and soak in the relaxed atmosphere, complete with local food stands and traditional Hawaiian culture.

Planning Your Drive

Before you set out on any of these highways, a bit of preparation will go a long way toward enhancing your trip. Check conditions, map out key stops, and leave room for unexpected adventures. With so many iconic highways and incredible sights, all that’s left to do is pack up, start your engine, and discover the beauty of America’s roads, one mile at a time.